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Scientific Studies

CISSUS QUADRANGULARIS – A safe and effective alternative in osteoporosis treatment

CISSUS QUADRANGULARIS – A safe and effective alternative in osteoporosis treatment


The Cissus quadrangularis, invites attention of the researchers worldwide for its pharmacological activities such as analgesic, anti-inflammatory, antioxidant and free radical scavenging activity, anti-osteoporosis activity and bone healing activity.

Cissus quadrangularis is a perennial plant of the grape family. It is commonly known as Veldt Grape. The plant commonly known as “bone setter”- it is referred to as Asthisandhani in Sanskrit and Hodjod in Hindi because of its ability to join bones. It is used as a medicinal plant with tonic and analgesic properties. It is also used to heal broken bones, injured ligaments and tendons, thus its name asthisamharaka (that which prevents the destruction of bones).

Osteoporosis is a disease of bones that leads to an increased risk of fracture. Osteoporosis is a silent epidemic disease. It has become a major health hazard in the recent years afflicting over 2000 million people worldwide. It is a chronic, progressive condition associated with micro-architectural deterioration of bone tissue that results in low bone mass.


Osteoporosis itself has no symptoms. Its main consequence is the increased risk of bone fractures. Osteoporosis fractures occur in situations where healthy people would not normally break a bone. Therefore it is regarded as fragility fractures. Typical fragility fractures occur in the vertebral column, rib, hip and wrist.

Numerous studies conducted on Cissus quadrangularis have shown several beneficial effects both in terms of quantity as well as to speed up the process of bone regeneration. Phytoestrogens in the extract accelerates osteogenesis (bone formation) and actively contributes to bone remodeling and bone matrix architecture recovery. Thanks to the antioxidants the inflammatory process is reduced.

RENFORCE has a formula specifically designed to halt osteoporosis degeneration.

Each Renforce capsule contains:

  • Cissus quadrangularis extract -250mg
  • Emblica officinalis  extract -100mg
  • Soia izoflavones – 50mg

Use for:

  • Osteomalacia
  • Osteopenia
  • Bone fragility
  • Fractures
  • Osteoporosis



  • One capsule, twice per day with plenty of water, just after meals.