Citicoline in apoptosis
Citicoline accelerates brain remodeling post stroke, acting on:
But before the initiation of the recovery mechanisms, it is important to be reduce teh edema and apoptosis installed immediately post-stroke.
Mechanisms of action of citicoline in apoptosis:
Citicoline reduces the accumulation of extracellular glutamate after ischemia by a dual mechanism involving both decrease neuronal glutamate efflux and an increase in absorption by the astrocytic of the glutamate.
Glutamate, an excitatory neurotransmitter, has long been recognized as a key factor in the pathophysiology of ischemia, due to excessive accumulation into the extracellular space and subsequent activation of its receptors, especially N-methyl-D aspartate (NMDA) (Castillo et al, 1996; . Choi and Rothman, 1990). Inhibition of glutamate actions proved to be a very powerful strategy to reduce ischemic brain lesions.
- stimulates the synthesis of phosphatidylcholine and sphingomyelin
- inhibit activation of phospholipase.
- inhibits the activation of caspase involved in neuronal apoptosis.