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Scientific Studies




Silymarin – the first hepatoprotective remedy used in the world proves its efficiency nowadays also

Silymarin is the dry extract from the seeds of Silybum marianum (milk thistle) and is made of a complex of flavonoids, mainly composed of silybin, silidianin and silicristin. Silybin is the most important and is the major component of silymarin. For thousands of years, this natural substance is considered the best remedy for liver diseases. Silymarin increases the ability of liver cells to resist the action of toxins, stimulate liver detoxification function, synthesis function of hepatocytes, thus increasing the capacity for regeneration. It protects the integrity of the cell membrane of hepatocytes by preventing penetration into liver cells of hepatotoxic substances (like alcohol, toxic chemicals , liver – toxic medications, toxins resulting from food processing etc.). Silymarin also reduce the risk of developing gallstones and promote digestion by fluidizing and eliminating the bile from gallbladder.

In chronic liver diseases caused by excessive oxidative stress (alcoholic fatty liver diseases, drug- and chemical-induced hepatic toxicity), the antioxidant medicines such as silymarin have beneficial effect. The silymarin exerts membrane-stabilizing and antioxidant activity, it promotes hepatocyte regeneration; furthermore it reduces the inflammatory reaction, and inhibits fibrogenesis in the liver. These results have been established by experimental and modern clinical trials.

According to these studies the long-term administration of silymarin significantly increased survival time of patients with alcohol induced liver cirrhosis. Based on the results of studies using methods of molecular biology, silymarin can significantly reduce tumor cell proliferation.

Milk thistle/Silymarin is widely used in the treatment of viral hepatitis (particularly hepatitis C, but not only), where showed good results to increase the quality of life in patients with acute or chronic hepatitis.

ESENTIN FORTE is a unique nutritional supplement in Romania, which contains 400 mg of Essential Phospholipids and 100 mg Silymarin in each capsule. The greatest benefit of these two liver protective substances combined in one capsule is that Essential Phospholipids, in addition to their beneficial role in the liver, helps Silymarin to enter into the liver cells, thus increasing the efficiency of its hepato protective action. Therefore we can say that ESENTIN FORTE is the strongest association available to those who want a healthier and protected liver. It is recommended to take 2-3 capsules ESENTIN FORTE daily for at least 3 months.