The role of Iron in the human body
• Iron participates in the synthesis of Mioglobin, which represents the tank with Oxigen for muscular tissues
• Iron is present in the enzymes of the cells (cytochromes, peroxidase, catalase)
• Iron enters in the structure of some enyzmes with the role in the DNA synthesis
• Iron increases the resistance to infections
• The iron deficiency reduces the activity of these enzymes – upset of the cell metabolism
• Iron deficiency develops a sequence of trophic changes in the tissues.
· The human body contains , generally, approx. 4-5 g of iron
• About 60-70 % of the iron in the organism is found associated to the hemoglobin of erythrocytes (about 3 grams)
• 3% is related to mioglobin
• 15% related to enzyms ( the cells of the nervous system)
• 20- 30% related to ferritin and hemosiderin
• 0,1% related to transferrin
• As reserves of iron, it is stored in the liver and macrophages of histiocytic-reticular system in the form of ferritin and hemosidorină.
• Permanent destruction of red blood cells releases iron from hemoglobin, which is reused by the body in the synthesis of new red blood cells.
• Loss of iron are generally very small. They are produced by flaking skin, mucous membranes and through sweat, urine, defecation. A loss of 1 mg iron per day for an adult male is considered normal and can be compensated by the iron content of food.
• For women, in the menstrual period, daily losses increase up to 3 mg per day.
• Because only 5-10% of the iron you get the food in the intestines can absorb and how daily requirement should be above 2 mg iron recovery food should contain more than 20 mg of iron.
Liposomal Delivery Systems
· Liposomes are spherical vesicular structures with size between 20 nm and 10 micrometres, made up of a phospholipid bilayer molecules.
· In these structures can be embedded active molecules.
Liposomes have become in the pharmaceutical industry, vehicles for transport and for controlled release of active substances in the body due to the advantages they present:
- are non-toxic and bioavailable
- they can be incorporated in both: hydrophilic or lipophilic substances
- can optimize the circulation time of the active substance
- can be achieved directly target organs or target tissues
- the side effects and the toxicity of the active substance are reduced in their case
- they improve the bioavailability